The Uveitis Clinic, coordinated by Dr. Daniele De Geronimo, is a specialized service dedicated to the diagnosis, treatment, and monitoring of uveitis—rare inflammatory eye diseases that can affect people of all ages and, if not properly treated, may lead to severe visual impairment.

Depending on the affected ocular region, uveitis can be classified as anterior, intermediate, posterior, or diffuse, and may involve only the eye itself or represent the ocular manifestation of systemic diseases, such as autoimmune or infectious diseases.

Through the integration of clinical care and scientific research, the clinic provides a comprehensive and personalized approach.
Patients undergo a diagnostic pathway that includes a complete specialized ophthalmologic examination, supported by advanced ocular imaging with state-of-the-art technology such as OCT, OCT-angiography, fluorescein angiography, and indocyanine green angiography (both standard and ultra wide-field).

When necessary, targeted laboratory tests are carried out for immunological and/or infectious disease evaluation, often in collaboration with other specialists such as rheumatologists, immunologists, or infectious disease experts, ensuring a truly multidisciplinary approach.

Once the diagnostic assessment is complete, a personalized treatment plan is developed.
In infectious uveitis, specific therapy (e.g., antibiotics and/or antivirals) is administered, often combined with corticosteroid anti-inflammatory treatment.
In developed countries, most uveitis cases are non-infectious, typically of inflammatory or autoimmune origin. The gold standard first-line therapy for non-infectious uveitis is corticosteroid treatment—administered topically (eye drops), locally (subconjunctival, sub-Tenon’s, peribulbar, or intravitreal injections), or systemically (oral, intramuscular, or intravenous routes).

For patients with recurrent or chronic uveitis requiring “steroid-sparing” strategies, or for those with inadequate response or contraindications to corticosteroids, second-line treatments such as traditional immunosuppressants or biologic agents are often necessary. In selected cases, intravitreal anti-VEGF injections may also be used.

The clinic’s goal is to control inflammation, prevent complications, and preserve visual function. Regular follow-up is essential to monitor disease progression and adjust therapy over time.

The Uveitis Clinic also participates in international multicenter clinical studies and research protocols, offering patients access to innovative therapies, including next-generation biologic drugs.