PUBLICATIONS 2025
Publications of the IRCCS G.B. Bietti Foundation for the Study and Research in Ophthalmology ONLUS.
For more information, please write to:
1)“Label-free determination of diffusion coefficients at the nanoscale through modelling of the Surface Plasmon Resonance signal”
Zingale G A, Pandino I, Calacagno D, Perina M L, Tuccitto N, Grasso G
PLoS One. 2025 Jan 7;20(1):e0312594. https://doi.org/10.1371/journal.pone.0312594
2)”Preservative-Free Bimatoprost 0.01% Ophthalmic Gel for Glaucoma Therapy: A Phase III Randomized Controlled Trial”
Muñoz-Negrete Francisco J , Tpouzis F, Oddone F, Nissle S, Rokicki D, Januleviciene I, Harasymowycz P, Stalmans I.
J Glaucoma. 2024 Jun 1;33(6):422-430. https://doi.org/10.1097/IJG.0000000000002371
3)”Safety and Longevity of Intraocular Pressure Control After Bimatoprost Implant Administration: Interim Analysis of a Phase 3b Clinical Trial (TRITON)”
Silverstein S M, Oddone F, Kolko M, Brinkmann C K, Christie W C, Bicket A K, Gous P NJ, Luebke J, Maram J, Nguyen A, Craven E R, Pu Y, Jiao J, BejanianM, Robinson MR, TRITON Studt Group
Drugs. 2025 Apr;85(4):557-570. https://doi.org/10.1007/s40265-025-02154-4
4)“A phase III study comparing preservative-free latanoprost eye drop emulsion with preserved latanoprost in open-angle glaucoma or ocular hypertension”
Baudouin C, Stalmans I, Bourne R, Larrosa JM, Schmickler S, Seleznev A, Oddone F, Phase III Study Group
Eye (Lond). 2025 Feb 25. https://doi.org/10.1038/s41433-025-03646-z
5)“Italian glaucoma virtual clinics: Developing a consensus for remote patient management”
Matarazzo F, Cutolo CA, Rabiolo A, Figus M, Fea A, Gandolfi S, Gizzi C, Manni G, Marchini G, Montesano G, Nucci C, Passaro ML, Romano D, Rossetti L, Sacchi M, Tanga L, Traverso CE, Triolo G, Virgili G, Oddone F, Costagliola C.
Acta Ophthalmol. 2025 Mar 17. https://doi.org/10.1111/aos.17484
6)”Vascular Density and Retinal Structure Relationships Across Sectors and Regions of the Optic Nerve in Patients With Primary Open Angle Glaucoma”
Ritzer L, Harris A, Arciero J, Siesky B, Fry B, Januleviciene I, Oddone F, Carnevale C, Eckrt G, Verticchio Vercellin A.
J Glaucoma. 2025 Apr 1;34(4):267-274. https://doi.org/10.1097/IJG.0000000000002536
7)“Medical and surgical treatment management in open angle glaucoma patients of Asian descent: A narrative review”
Belamkar A V, Harris A, Wirotsko B, Rowe L, Oddone F, Carnevale C, Verticchio Vercelli A, Kanwar K, Wood K, Fabczak-Kubicka A, Siesky B,
Eur J Ophthalmol. 2025 May 19:11206721251340435. https://doi.org/10.1177/11206721251340435
8)“Efficacy and Safety of XEN63 Gel Stent Implant over 6 Months for Treatment of Glaucoma”
Sacchi M, Giammaria S, Roberti G, Tomaselli D, Monsellato G, Agnifili L, Posarelli C, Abbruzzese G, Ronchi L, Tatti F, Dore S, Giannaccare G, Nucci P, Pinna A, Figus M, Oddone F.
J Clin Med. 2025 Apr 28;14(9):3036. https://doi.org/10.3390/jcm14093036
9)”Artificial intelligence for glaucoma”
Vemulapalli K, Gandhewar R, Safitri A, Ng S M, Michelessi ;, Azuara-Blanco A, Liu S H, Virgili G, Hu K.
Cochrane Database Syst Rev. 2025 Jun 17;6(6):CD016114. https://doi.org/10.1002/14651858.cd016114
1)“A Pilot Case Series on the Use of a Large Mushroom-Shaped Corneal Graft for the Surgical Management of Post-Penetrating Keratoplasty Ectasia and Endothelial Failure “
Moramarco A, Fontana L, Di Geronimo N, Rapezzi G, Savini G, Viola P, Mete M, Romano V.
J Clin Med. 2025 Jan 8;14(2):343. https://doi.org/10.3390/jcm14020343
2)”Comparison of intraocular lens power formulas for negative diopter intraocular lens implantation for high myopia”
Whang WJ, Koh K, Hoffer K J, Schiano Lomoriello D, Lupardi E, Taroni L, Tchah H, Savini G.
J Cataract Refract Surg. 2025 Feb 1;51(2):119-125. https://doi.org/10.1097/j.jcrs.0000000000001569
3)“The Influence of Anterior Chamber Depth on the Calculation of Piggyback Intraocular Lenses”
Buonsanti D, Hoffer K J, Coutinho C P, Savini G.
Am J Ophthalmol. 2025 Apr:272:161-165. https://doi.org/10.1016/j.ajo.2025.01.013
4)”Repeatability and reproducibility of a new spectral-domain optical coherence tomography biometer and agreement with swept-source optical coherence tomography based biometer”
Li X, Lei C S, Ning R, Liu L, Chen A, Yang X, Savini G, Schiano Lomoriello D, Zhou X, Huang J.
Eye Vis (Lond). 2025 Feb 1;12(1):6. https://doi.org/10.1186/s40662-024-00422-0
5)“Influence of preoperative variables on the 3-month functional outcomes of the Vivity extended depth-of-focus intraocular lens: a prospective case series”.
Savini G, Galzignato A, Coutinho C P, Huang J, Wu Y, Barboni P, Dias J M, Ribeiro F J, Schiano Lomoriello D.
Eye Vis (Lond). 2025 Feb 2;12(1):8. https://doi.org/10.1186/s40662-024-00424-y
6)“Which Test Is Best: Evaluation of Traditional and Contemporary Statistical Tests for Analysis of Spherical Equivalent Prediction Error”
Cannon N T, Savini G, Pantanelli S M, Hoffer K, Aristodemou P, Riaz K, Murphy D, Griffini D, Berry C, Debellemanière G, Gauvin M, Wallerstein A, Whang W J, Koh K, Negishi K, Hayashi K, Hipolito-Fernandes D, Cooke D L.
Am J Ophthalmol 2025 Feb 7:273:33-42. https://doi.org/10.1016/j.ajo.2025.01.022
7)”Repeatability of automatic measurements by a new spectral domain optical coherence biometer and agreement with a validated biometer”
Grendele A, Galzignato A, Hoffer K J, Coutinho C P, Calossi F, Schiano Lomoriello D, Savini G.
J Cataract Refract Surg 2025 Mar 10. https://doi.org/10.1097/j.jcrs.0000000000001650
8)“Evaluation of a New Fully Automatic OLCR Biometer: Repeatability, Reproducibility, and Agreement with an SS-OCT Biometer”
Chak Seng Lei, Xinning Yang, Rui Ning, Jinxuan Xiahou , Xinyu Jiang, Savini G, Schiano Lomoriello D, Xingtao Zhou, Kexin Li, Jinhai Huang
Ophthalmol Ther. 2025 May;14(5):1097-1109. https://doi.org/10.1007/s40123-025-01120-3
9)“Optical confirmation by a thick-lens formula of the optimized A-constant (as calculated by a thin-lens formula) of a new intraocular lens”.
Savini G, Nicolosi D, Hoffer K J, Coutinho C P, Curatolo M C, Schiano Lomoriello D.
J Cataract Refract Surg. 2025 Apr 10. https://doi.org/10.1097/j.jcrs.0000000000001671
10)“IOL Power Calculation Project: Accuracy of 36 Formulas”.
Voytsekhivskyy O V, Hoffer K J, Cooke D, Savini G.
Am J Ophthalmol. 2025 May 12:277:45-56. https://doi.org/10.1016/j.ajo.2025.05.004
11)”Comparison of IOL formula accuracy for eyes with prior scleral buckle surgery”.
Kong A W, Jeon M J, Lin S R, Bartlett J D, McCannel C A, Hoffer K J, Savini G, Nejad M.
J Cataract Refract Surg. 2025 Jun 9. https://doi.org/10.1097/j.jcrs.0000000000001715
12)“Machine Learning Applied to Visual Fields of Dominant Optic Atrophy Patients”.
Coutinho C P, Zanchetta F, Carbonelli M, Battista M, Galzignato A, La Morgia C, Amore G, Romagnoli M, Savini G, Brotto L, Nucci P, Caporali L, Bandello F, Carelli V, Cascavilla M L, Barboni P.
Transl Vis Sci Technol. 2025 Jun 2;14(6):20. https://doi.org/10.1167/tvst.14.6.20
13)“Theoretical Influence of segmented axial length on IOL Power calculation in short eyes”.
Savini G, Hoffer K J, Nicolosi P D, Cooke D, Coutinho C P, Grendele A, Schiano Lomoriello D.
Journal of Cataract & Refractive Surgery http://dx.doi.org/10.1097/j.jcrs.0000000000001711
14)“Normative Values on Stromal Curvature, Power and Corneal-Stromal Curvature Ratios From a Hybrid AS-OCT”
Wandelstein J A, Grendele A, Langenbucher A, Galzignato A, Coutinho C P, Pantanelli S, Riaz K M, Savini G. Clin Exp Ophthalmol. 2025 May 22. https://doi.org/10.1111/ceo.14556
15)”Precision of Corneal Aberrometric Measurements With a New Hybrid Device and Comparison With a Scheimpflug/Placido Topography in Different Grades of Keratoconus”.
Rui Ning, Yizhou Yang, Huilin Xu, Kexin Li, Zheng Li, Yue Li, Savini G, Schiano Lomoriello D, Xingtao Zhou, Xiaoying Wang, Jinhai Huang
J Refract Surg, 2025 May;41(5): e460-e471. https://doi.org/10.3928/1081597x-20250401-03
16)“Comparison of Anterior Segment Measurements With a New Swept-source Optical Coherence Tomography Biometer and a Scheimpflug-Placido Topographer”.
Chak Seng Lei, Xin Li, Huilin Xu, Rui Ning, Yiran Wang, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Kexin Li, Jinhai Huang
J Refract Surg. 2025 May;41(5): e413-e420. https://doi.org/10.3928/1081597x-20250317-03
1)”Type 3 Macular Neovascularization in Age-related Macular Degeneration: Baseline Predictors of 3-Year Macular Atrophy Development”
Sacconi R, Forte P, Corradetti G, Costanzo E, Capuano V, Bousquet E, Beretta F, Iannuzzi S, Polito M S, Nicolò M, Parravano M, Souied E, Sarraf D, Sadda S V, Bandello F, Querques G.
Ophthalmol Retina. 2024 Nov 19:S2468-6530(24)00541-4.
https://doi.org/10.1016/j.oret.2024.11.011
2)“Faricimab versus the standard of care for neovascular age-related macular degeneration in Italy: an indirect treatment comparison”
Galeone C, Turati F, Nicolò M, Parravano M, Vujosevic S, Bianchino L, Sicari E, Lanzetta P.
Drug Target Insights. 2024 Dec 12:18:105-111. https://doi.org/10.33393/dti.2024.3213
3)”Microcystoid Macular Edema in Epiretinal Membrane: Not a Retrograde Maculopathy”
Govetto A, Francone A, Luccini S, Garavaglia S, Carini E, Virgili G, Radice P, Vogt D, Edwards M, Spaide R F, Romano M R.
Am J Ophthalmol. 2025 Apr:272:48-57. https://doi.org/10.1016/j.ajo.2024.12.027
4)“Real-world evidence of anti-VEGF therapies in patients with neovascular age-related macular degeneration in Italy: The RADIANCE study”
Parravano M, Viola F, Nicolò M, Vujosevic S, Bianchino L, Sicari E, Villa G, Lanzetta P.
Eur J Ophthalmol. 2025 Feb 3:11206721241310628. https://doi.org/10.1177/11206721241310628
5)”Prevalence of dry eye disease among children: a systematic review and meta-analysis”
Zou Y, Li D, Virgili G, Condon N, Piyassena P, PrakalapakomS G, Zhang R, Zhao Z, Fai Chan V, Yu M.
BMJ Open Ophthalmol. 2025 Feb 19;10(1):e002014. https://doi.org/10.1136/bmjophth-2024-002014
6)”Retinal detachment incidence in refractive lens exchange versus cataract surgery: uncommon versus rare – systematic review and meta-analysis”
Passaro M L, Kilic D, Virgili G, Romano V, Lucenteforte E, Dick B, Taneri S.
Br J Ophthalmol. 2025 Feb 27:bjo-2024-326592. https://doi.org/10.1136/bjo-2024-326592
7)”Retinal Dystrophies Associated with Mutations in the RP1Gene: Genotype-Phenotype Correlations”
Spagnuolo V, Piergentili M, Passerini I, Murro V, Mucciolo D P, Giorgio D, Maccari M, Pelo E, Biagini I, Giansanti F, Virgili G, Sodi A.
Curr Issues Mol Biol. 2025 Mar 20;47(3):212. https://doi.org/10.3390/cimb47030212
7)“Real-World Intravitreal Aflibercept 2 mg Treatment of Macular Oedema Secondary to Retinal Vein Occlusion in Italy: 24-Month Results from the AURIGA Observational Study”
Grassi M O, Russo A, Vadalà M, Allmeier H, Machewitz T, Varano M, AURIGA Study Investigators
Ophthalmologica. 2025 Apr 9:1-14. https://doi.org/10.1159/000545534
8)“Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: A Systematic Review and Meta-Analysis”
Ghilardi A, Fan S, Mercieca K, Virgili G, De Cillà S, Rabiolo A.
Ophthalmol Glaucoma. 2025 Apr 19:S2589-4196(25)00072-9. https://doi.org/10.1016/j.ogla.2025.04.004
9)“Femtosecond laser-assisted in situ keratomileusis for the correction of residual ametropia after penetrating keratoplasty: 1-year follow-up”
Mucciolo D P, Albani G, Terracciano L, Branchetti M, Luchetti L, Murro V, Virgili G, Giansanti F.
Front Ophthalmol (Lausanne). 2025 Apr 11:5:1562555. https://doi.org/10.3389/fopht.2025.1562555
10)“Evaluating the burden of caregivers of patients with visual impairment: a multicenter pilot study in Italian visual rehabilitation centers”
Virgili G, Ferron F, Bartolomei F, Van Nispen R, Costanzo E, Ciaffoni G L, Rellini E, Turco S, Piepoli M, Di Pietro S, Fortini S.
Front Public health, 06 June 2025 Sec. Public Mental Health Volume 13, 2025
https://doi.org/10.3389/fpubh.2025.1530172
11)“Geographic Atrophy and Peripheral Atrophy: Quantitative Analysis with Ultra-Widefield Autofluorescence”
De Geronimo D, Parravano M, Sacconi R, Costanzo E, Varano M, Querques G.
Ophthalmologica. 2025 Apr 8:1-7. https://doi.org/10.1159/000544958
12)“Behçet’s disease: A review of the ophthalmologic findings reported in Behçet’s original descriptions”
Accorinti M, Gilardi M, Cecere M, Ohno S, De Geronimo D.
Saudi J Ophthalmol. 2025 Feb 14;39(1):41-46. https://doi.org/10.4103/sjopt.sjopt_216_24
13)”Updates on novel and traditional OCT and OCTA biomarkers in nAMD”
Crincoli E, Parravano M, Sacconi R, Costanzo E, Polito M S, Ferro Desideri L, Querques G.
Eye (Lond). 2025 Jun;39(9):1662-1672. https://doi.org/10.1038/s41433-025-03801-6
14)”Evidence and Consensus-Based Imaging Guidelines in Multifocal Choroiditis With Panuveitis and Punctate Inner Choroiditis-Multimodal Imaging in Uveitis (MUV) Taskforce Report 5”
Gangaputra S, Agarwal A, Ossewaarde-van Norel J, Tsui E, E Thoren J, De-la-Torre A, Altraweel M, Biswas J, Sadda S, Invernizzi A, Agrawal R, Shanta J G, Accorinti M, Fawzi A, Jabs D A, Sarraf D, Gupta V, Multimodal Imaging in Uveitis (MUV) Task force
Am J Ophthalmol. 2025 Apr 25:276:272-285. https://doi.org/10.1016/j.ajo.2025.04.018
1)“Internal Limiting Membrane Flaps in Macular Hole Surgery: A Systematic Review and Individual Participant Data Meta-analysis”
Tzoumas N, MCNally T W, The B L, Zaman M, Yorston D, Lois N, Chaudhary V, Steel D H, ILM Flap Study Group
Ophthalmol Retina. 2025 Feb 7:S2468-6530(25)00055-7. https://doi.org/10.1016/j.oret.2025.02.003
2)”Comparing the Efficiency of Valved Trocar Cannulas for Pars Plana Vitrectomy”
Rossi T, Querzoli G, Angelini G B, Pellizzaro C, Santoro V, Rosari G, Parravano M, Romano M R. Bioengineering (Basel). 2025 Apr 19;12(4):431. https://doi.org/10.3390/bioengineering12040431
3)Comparing the Efficiency of Fluid Infusion Systems for Pars Plana Vitrectomy”
Rossi T, Querzoli G, Angelini G B, Santoro V, Pellizzaro C, Steel D H, Parravano M, Romano M R.
Transl Vis Sci Technol. 2025 May 1;14(5):10. https://doi.org/10.1167/tvst.14.5.10
1)Universally Present and Co-Localize With Intraretinal Fluid in Diabetic Macular Edema”
Midena E, Frizziero L.
Invest Ophthalmol Vis Sci. 2025 Feb 3;66(2):59. https://doi.org/10.1167/iovs.66.2.59
2)”Disorganisation of inner retinal layers in diabetic macular oedema: is it time to standardise this OCT biomarker?”
Danieli L, Midena G, Frizziero L, Midena E.
Br J Ophthalmol. 2025 Feb 27:bjo-2024-326843. https://doi.org/10.1136/bjo-2024-326843
3)”Neurofibromatosis type 1 (NF1)-related ocular signs: new insights on their prevalence, incidence and genotype-phenotype correlation in NF1 children”
Midena E, Cosmo E.
Am J Ophthalmol. 2025 Mar 5:S0002-9394(25)00110-2. https://doi.org/10.1016/j.ajo.2025.02.044
4)“Hyperreflective retinal foci: definition and role of an invaluable OCT sign”
Frizziero L, Midena G, Danieli L, Torresin T, Perfetto A, Parrozzani R, Pilotto E, Midena E
J Clin Med. 2025 Apr 27;14(9):3021. https://doi.org/10.3390/jcm14093021
5)”Artificial intelligence-based assessment of imaging biomarkers in epiretinal membrane surgery”
Mariotti C, Mangoni L, Mui A, Fella M, Mogetta V, Bongiovanni G, Rizzo C, Chhablani J, Midena E, Lupidi M
Eur J Ophthalmol. 2025 Apr 27:11206721251337139. https://doi.org/10.1177/11206721251337139
Abagnale C, Di Renzo A, Giuliani G, Sebastianelli G, Casillo F, Ziccardi L, Parisi V, Di Lorenzo C, Serrao M, Caramia F, Di Piero V, Coppola G.
J Headache Pain. 2025 Jan 15;26(1):12. https://doi.org/10.1186/s10194-024-01920-1
2)“Assessment of hypothalamic macrostructure in episodic cluster headache: a volumetric segmentation MRI study”
Chiffi D, Di Renzo A, Giuliani G, Abagnale C, Altieri M, Sebastianelli G, Casillo F, Di Piero V, Coppola G, Caramia F.
Radiol Med. 2025 Jun 27. https://doi.org/10.1007/s11547-025-02041-8
1)”VEGFR3 pathway in corneal transplantation”
Laborante M, Micera M, Gaudenzi D, De Luca A, De Gregorio C, Cutrupi F, Esposito G, Balzamino BO, Laborante A, Coassin M, Di Zazzo A.
Acta Ophthalmol. 2025 Feb 6. https://doi.org/10.1111/aos.17457
2)”Oncological Treatment Adverse Reaction Prediction: Development and Initial Validation of a Pharmacogenetic Model in Non-Small-Cell Lung Cancer Patients”
Cafiero C, Palmirotta R, Martinelli C, Micera A, Giacò L, Persiani F, Morrione A, Pastore C, Nisi C, Modoni G, Galeano T, Guarino T, Foggetti I, Nisticò C, Giordano A, Pisconti S.
Genes (Basel). 2025 Feb 24;16(3):265. https://doi.org/10.3390/genes16030265
3)”Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life”
Latina V, De Introna M, Malerba F, Florio R, Omar B O, Di Natale G, Sciacca MFM, Pappalardo G, Micera A, Pignataro A, Calissano P, Amadoro G.
Acta Neuropathol Commun. 2025 May 29;13(1):121. https://doi.org/10.1186/s40478-025-02022-y
4)“Ceruloplasmin and Ferritin Changes in Ocular Fluids from Patients with Vitreoretinal Diseases: Relation with Neuroinflammation and Drusen Formation.”
Esposito, G.; Cosimi, P.; Balzamino, B.O.; Bruno, M.; Squitti, R.;
Dinice, L.; Scarinci, F.; Rongioletti, M.C.A.; Cacciamani, A.; Micera, A.
Int. J. Mol. Sci. 2025, 26, 6307. https://doi.org/10.3390/ ijms26136307
1)“Nitrite binding to myoglobin and hemoglobin: Reactivity and structural aspects”
Ascenzi P, De Simone G, Zingale GA, Coletta M.
J Inorg Biochem. 2025 Apr:265:112829. https://doi.org/10.1016/j.jinorgbio.2025.112829
2)“Label-free determination of diffusion coefficients at the nanoscale through modelling of the Surface Plasmon Resonance signal”
Zingale G A, Pandino I, Calacagno D, Perina M L, Tuccitto N, Grasso G
PLoS One. 2025 Jan 7;20(1):e0312594. https://doi.org/10.1371/journal.pone.0312594
3)“Broad-Spectrum Diffusion Coefficient Measurements via Surface Plasmon Resonance: From Thermodynamics to Protein Conformational Disorders”
Basile G S, Calcagno D, Tuccitto N, Sbardella D, Grasso G.
Chemphyschem. 2025 Jun 29:e2500138. https://doi.org/10.1002/cphc.202500138
1)“RETINAL DISPLACEMENT AFTER IDIOPATHIC MACULAR HOLE SURGERY: Layer by Layer Analysis”
Rossi T, Querzoli G, Ripandelli G, Placentino L, Parravano M, Steel D H, Romano M R,
Retina. 2025 Mar 1;45(3):410-419. https://doi.org/10.1097/IAE.0000000000004352
2)“Profiling of the Peripheral Blood Mononuclear Cells Proteome by Shotgun Proteomics Identifies Alterations of Immune System Components, Proteolytic Balance, Autophagy, and Mitochondrial Metabolism in Glaucoma Subjects”
Giammaria S, Pandino I, Zingale G A, Atzori M A, Cavaterra D, Cecere M, Michelessi M, Roberti G, Tanga L, Carnevale C, Verticchio Vercellin A, Siesky B, Harris A, Grasso G, Bocedi A, Coletta M, Tundo G R, Oddone F, Sbardella D.
ACS Omega. 2025 Apr 9;10(15):14866-14883. https://doi.org/10.1021/acsomega.4c10035
(Lavoro in condivisione tra la UR di Glaucoma e la UR Laboratorio di Proteomica)