Skip to content

Dr. Ferrazza Manuela

Orthoptist, Assistant in Ophthalmology
Head of Clinical Trial Center
Ospedale Britannico
Research unit: Clinic trial center
Professional register: Ordine dei tecnici sanitari di radiologia medica e delle professioni sanitarie tecniche della riabilitazione e della prevenzione di Roma e Provincia n.1 del 23.11.2018

Practices at IRCCS Fondazione G.B. Bietti in the premises of Via Livenza, 3 and Via di Santo Stefano Rotondo, 6, at the Britannico Hospital, Rome.

Scientific Publications: PubMed

LinkedIn Profile: Manuela Ferrazza

 

  • 2004 – 2008: Bachelor’s Degree in Orthoptics and Ophthalmologic Assistance, University of Rome Tor Vergata – Faculty of Medicine and Surgery (Final grade: 100/110).
    Thesis: Evaluation of ocular motility in subjects with mild and severe signs and symptoms of thyroid ophthalmopathy.

  • 1999 – 2004: Diploma in Optics (Final grade: 84/100), Professional Qualification as Optician (Final grade: 80/100), Certificate as Optical Operator (Final grade: 81/100).
    I.P.S.I.A. Edmondo De Amicis, Rome – Optics Program.

  • 2023 – present: Permanent employee, Clinical Trial Center Manager, IRCCS G.B. Bietti, Rome.
  • 2016 – 2023: Permanent employee, Orthoptist and Assistant in Ophthalmology, IRCCS G.B. Bietti, Rome.
  • 2013 – 2015: Contractor, Orthoptist and Assistant in Ophthalmology, Glaucoma Research Line, IRCCS G.B. Bietti, Rome.
  • 2010 – 2012: Research Fellow, Orthoptist and Assistant in Ophthalmology, Glaucoma Research Line, IRCCS G.B. Bietti, Rome.
  • 2004 – 2010: Optician, various optical centers, Rome.
  • Management of the Clinical Trial Center.
  • Technical support activities for scientific research of the Glaucoma Unit

Study Coordinator in the following clinical trials:

  • Efficacy and safety assessment of T4030 eye drops versus Ganfort® UD in ocular hypertensive or glaucomatous patients (LT4030-301).

  • A Phase 3b Study to Evaluate the Duration of Effect of Bimatoprost SR in Participants with Open-Angle Glaucoma or Ocular Hypertension (TRITON 1698-301-007).

  • Basic human research study of novel glaucoma endpoints and identification of optimal patient populations for neuroprotection trials (CBASICHR0031).

  • Evaluation of spatial summation in the central 10 degrees of the visual field: development of a neural model for structure-function analysis.

  • Phase III, multinational, multicenter, investigator-masked, randomized, active-controlled study to compare the efficacy and safety of DE-130A versus Xalatan® in patients with open-angle glaucoma or ocular hypertension over 3 months, followed by a 12-month open-label follow-up with DE-130A treatment (CATIOPROST – 0130A01SA).

Sub-Investigator in the following clinical trials:

  • Modulation of neuronal connectivity along the visual pathways in glaucoma patients through oral citicoline solution treatment: a multimodal morpho-functional study.

  • 24-hour efficacy and tolerability of the preservative-free fixed-dose tafluprost-timolol combination in glaucomatous or ocular hypertensive patients previously treated with BAK-preserved latanoprost. A 3-month prospective, open-label study (HERO).

  • Evaluation of agreement in the diagnosis of glaucoma progression by visual field testing.

  • Using crowd-sourced assessment by glaucoma specialists to establish a glaucoma definition for clinical research (CSGS).

  • Evaluation of the efficacy and safety of T4032 (bimatoprost 0.1% preservative-free) versus Lumigan 0.01% in patients with ocular hypertension or glaucoma (LT4032-301).

  • Measurement of test-retest variability in glaucoma patients using Compass fundus perimeter (CMP-003).

  • Evaluation of the effect on visual function of liposomal citicoline eye drops as an adjunct to IOP-lowering therapy in glaucoma patients (OMK1_LF).

  • Evaluation of vitreous citicoline concentration after topical ocular administration: ocular pharmacokinetics study in humans (OMK12017).

  • A prospective, double-masked, randomized, multicenter, active-controlled, parallel-group, 6-month study assessing the safety and IOP-lowering efficacy of PG324 Ophthalmic Solution compared to GANFORT® (bimatoprost 0.03%/timolol 0.5%) in subjects with elevated IOP (MERCURY 3).

  • Preservative-free fixed-dose combination of tafluprost 0.0015% / timolol 0.5% in open-angle glaucoma or ocular hypertension: clinical effectiveness, tolerability, and safety in a real-world setting.

  • Efficacy of a taurine and hyaluronic acid ophthalmic solution in glaucoma and ocular hypertension patients under chronic IOP-lowering treatment.

  • Safety and efficacy of twice-daily brinzolamide 1%/brimonidine 0.2% (SIMBRINZA) as adjunctive therapy to travoprost 0.004%/timolol 0.5% (DUOTRAV).

  • Intraocular pressure and tolerability study of preserved bimatoprost 0.1% (BMD) or preservative-free tafluprost (Saflutan®) in ocular hypertension or glaucoma patients: randomized, single-masked, 3-month, crossover, European multicenter trial (SPORT II).

  • Clinical performance of Compass in the diagnosis of glaucoma.

  • A phase IV study on ocular signs and symptoms in patients with ocular hypertension or open-angle glaucoma switched from Ganfort® to Taptiquom® eye drops.

  • Evaluation of plasma and tear levels of BDNF and NGF in glaucoma patients (NTs and glaucoma).

  • Side effects of preservatives: clinical, cytological, and instrumental evaluation of the ocular surface.

  • Intraocular pressure and tolerability study of preservative-free bimatoprost 0.03% (BUDPF) or preservative-free latanoprost 0.005% (LUDPF, Monoprost®) in ocular hypertension or glaucoma patients: randomized, single-masked, 3-month crossover, European multicenter trial (SPORT).

  • Comparison between bimatoprost-timolol fixed-dose combination and carbonic anhydrase inhibitor-timolol combinations in patients with glaucoma or ocular hypertension uncontrolled by monotherapy: retrospective study.

  • Efficacy of a cobalamin, taurine, and hyaluronic acid ophthalmic solution in patients under IOP-lowering therapy.

  • Evaluation of the IOP-lowering efficacy of Miotrab administered three times daily.

  • Lumigan® 0.1% in daily clinical practice: retrospective study.

  • Learning effect of Heidelberg Edge Perimeter (HEP) perimetry in ocular hypertension patients.

  • Effect of pupil dilation on RNFL, ONH, and GCC measurements with spectral-domain OCT (RTVue-100).

  • Prospective longitudinal study of ocular surface disease development in treatment-naïve ocular hypertension/glaucoma patients compared to healthy controls (SAHARA).

  • Therapeutic equivalence evaluation of Travoprost PR and Travatan®: randomized, double-masked study in glaucoma or ocular hypertension patients.

  • Two-year, multicenter, double-masked, parallel-group study assessing the safety of LUMIGAN® 0.1 mg/ml versus LUMIGAN® 0.3 mg/ml in glaucoma or ocular hypertension patients.

  • Phase III, randomized, double-masked, 6-month study comparing the preservative-free tafluprost 0.0015%/timolol 0.5% fixed-dose combination with individual monotherapies in open-angle glaucoma or ocular hypertension patients.

  • Comparison of circadian IOP-lowering effects of bimatoprost 0.01% versus timolol 0.5%.

  • Multicenter study on efficacy and tolerability of travoprost 0.004% with Polyquad® preservative in patients previously on latanoprost 0.005% or bimatoprost 0.01% monotherapy.

  • Evaluation of glaucomatous patients with RNFL abnormalities using SITA Standard and SITA SWAP perimetry.

  • Comparison between the Moorfields MDT and established perimeters to discriminate between normal and glaucomatous eyes.

Skip to content