The clinical trial is a trial protocol that aims to evaluate the effectiveness and possible side effects of a drug or a therapy


Volunteers have a leading role in research. In addition to contributing to research, they can participate in the most innovative treatments


As an IRCCS Research Institute, the Bietti Foundation initiates numerous experimental protocols in order to identify and promote the best therapies for different pathologies


The clinical trial is the latest step in the path of approval of therapies and drugs, and confers the latest answers to the investigations carried out in the laboratory

Open trials for recruiting

A phase III, randomised, multi-centre, double-blind, active-controlled study to evaluate the efficacy and safety of Faricimab in patients with macular oedema secondary to retinal or hemiretinal central vein occlusion.

Characterization of retinal disease progression in patients with non-proliferative diabetic retinopathy (npdr) in type 2 diabetes using non-invasive procedures.

Assessment of patient satisfaction in the management of wet age-related macular degeneration: survey of Italian patients.

Retinal and Cognitive Dysfunction in Type 2 Diabetes: unveiling common pathways and identifying patients at risk for dementia.

Basic human research study of new endpoints in glaucoma and identification of optimal patient populations for neuroprotective trials.

A Phase 3b study to evaluate the duration of effect of bimatoprost SR in participants with open-angle glaucoma or ocular hypertension.

Evaluation of the efficacy and safety of eye drops T4030 compared to single-dose Ganfort in patients with ocular hypertension or glaucoma.

XEN Glaucoma Treatment Registry (XEN-GTR)

24-hour efficacy and tolerability of the fixed combination tafluprost
-timolol without preservatives in glaucomatous or ocular hypertensive patients already treated with BAK preserved latanoprost. Prospective 3-month study.

Clinical trial to study the visual performance of hydrophobic monofocal IOL: Micropure 1.2.3.

Evaluation of the agreement between different Amsler grids in identifying the central functional defect in glaucomatous patients with reduction of the thickness of the ganglion cells measured with spectral-domain optical coherence tomography.

Assessment of β-amyloid concentration and intracellular proteolytic pathways in tissues and eye fluids of patients undergoing glaucoma surgery combined or non-combined with cataract surgery.

Case-control study of corneal pathophysiology using instrumental diagnostic techniques in healthy subjects and in patients suffering from ocular diseases and/or systemic diseases.

Evaluation of the effects and tolerability of RD03/2016 (Levofloxacin; Ketorolac Trometamol 0.5+0.5% w/v eye drops in solution) for the treatment of bacterial conjunctivitis in adults: a multicenter, randomized, blinded, phase II non-inferiority study – MIRACLE.

One-year, multicenter, single-arm, phase IV open-label study to identify early and innovative anatomical biomarkers predictive of retinal fluid resolution by multimodal imaging and support assessment of pathology activity in wAMD and patients treated with brolucizumab (IMAGINE Study).

Phase 3 follow-up study of aav5-hrkp.rpgr for the treatment of x-linked retinitis pigmentosa associated with rpgr gene variants.

Randomized, phase 3 controlled trial of AAV5-hRKp.RPGR for the treatment of X-linked retinitis pigmentosa associated with RPGR gene variants.

Modulation of neuronal connectivity along the visual pathways in glaucomatous patients by treatment with Citicoline oral solution: Multimodal Morpho-Functional study.

Observational study of neurodegenerative processes in patients with retinal and/or visual nervous system pathologies through innovative methods of morpho-functional evaluation of the different retinal elements and the different components of the optic pathways.

A Phase 3, multi-center, double-blind, randomized study to evaluate the efficacy and safety of intravitreal OPT-302 in combination with Aflibercept, compared to Aflibercept monotherapy, in participants with Neovascular age-related macular degeneration.

A Phase 2, randomised, multi-centre study to assess the dose level of multiple THR-149 injections and to evaluate the efficacy and safety of THR-149 versus aflibercept for the treatment of diabetic macular oedema.

Real-world study on anti-vegf treatments in neovascular age-related macular degeneration in Italy: real clinical practice analysis: The Radiance Study.

Evaluation of the efficacy of hypnosis of the PreserFlo device in combination or not with cataract surgery in glaucomatous patients: a multicenter retrospective “before-after” study.

Longitudinal prospective observational study for clinical assessment of visual field change in glaucoma. Evaluation of different progression models.

Evaluation of spatial summation in the central 10 degrees of the visual field: development of a neural model for structure-function analysis.

Performance of DRS Plus Retinography in Patients with Diabetes Mellitus.

Complete list of Foundation trials

As IRCCS, the G.B. Bietti Foundation has made research the beating heart of its activity. Our priority is to solve the still unanswered questions about pathologies, treatments, cures, and medicines. That’s why clinical trials are an essential part of our business in building effective and safe health for all.

Performance of DRS Plus Retinography in Patients with Diabetes Mellitus
Opened with enrollment completed
Opened with enrollment completed
Trial 3