Pubblicazioni 2021

Pubblicazioni dell’IRCCS Fondazione G.B. Bietti per lo Studio e la Ricerca in Oftalmologia ONLUS.

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1) Accuracy of optical coherence tomography for diagnosing glaucoma: an overview of systematic reviews

Michelessi M, Li T, Miele A, Azuara-Blanco A, Qureshi R, Virgili G.

Br J Ophthalmol. 2021 Apr;105(4):490-495.doi: 10.1136/bjophthalmol-2020-316152

2) Glaucoma and neuroinflammation: an overview

Quaranta L, Bruttini C, Micheletti E, Konstas A.G.P, Michelessi M, Oddone F, Katsanos A, Sbardella D, De Angelis G, Riva I.

Surv Ophthalmol. 2021 Feb 11;S0039-6257(21)00034-5. doi: 10.1016/j.survophthal.2021.02.003


3)What do we really know about the effectiveness of glaucoma interventions: An overview of systematic reviews

Qureshi R, Azuara-Blanco A, Michelessi M, Virgili G, Barbosa Breda J, Cutolo C, Pazos M, Katsanos A, Garhofer G, Kolko M, Prokosch V, Al Rajhi A.A, Lum F, Musch D, Gedde S, Li T

Ophthalmol Glaucoma. 2021 Feb 9;S2589-4196(21)00035-1



4) Endothelial Cell Density after XEN Implant Surgery: Short term Data from the Italian XEN Glaucoma Treatment Registry (XEN-GTR)

Oddone F, Roberti G, Posarelli C, Agnifili L, Mastropasqua L, Carnevale C, Micelli Ferrari T, Pace V, Sacchi M, Cremonesi E, Uva M, Menchini M, Brescia L, Figus M.

J Glaucoma. 2021 Apr 2. doi: 10.1097/IJG.0000000000001840

5) The interplay between lipid and Aβ amyloid homeostasis in Alzheimer’s Disease: risk factors and therapeutic opportunities

García-Viñuales S, Sciacca Michele F M, Lanza V, Santoro A M,  Grasso G, Tundo Grazia R, Sbardella D, Coletta M,  Grasso G, La Rosa C, Milardi D

Chem Phys Lipids. 2021 May;236:105072. doi: 10.1016/j.chemphyslip.2021.105072. 

6) Dexamethasone Downregulates Autophagy through Accelerated Turn-Over of the Ulk-1 Complex in a Trabecular Meshwork Cells Strain: Insights on Steroid-Induced Glaucoma Pathogenesis

Sbardella D, Tundo G R,  Coletta M, Manni G, Oddone F

Int J Mol Sci. 2021 May 31;22(11):5891. doi: 10.3390/ijms22115891.


7) Confocal Microscopy and Anterior Segment Optical Coherence Tomography Imaging of the Ocular Surface and Bleb Morphology in Medically and Surgically Treated Glaucoma Patients: A Review

Carnevale C, Riva I, Roberti G, Michelessi M, Tanga, Verticchio Vercellin Alice C,  Agnifili L, Manni G, Harris A, Quaranta L,  Oddone F

Pharmaceuticals 2021, 14(6), 581;


8) Comparison of preserved bimatoprost 0.01% with preservative-free tafluprost: A randomised, investigator-masked, 3-month crossover, multicentre trial, SPORT II

Lemmens S, Rossetti L, Oddone F, Sunaric-Mégevand G, Hommer A, Vandewalle E, Cordeiro M F, McNaught A,  Montesano G,  Stalmans I.

Eur J Ophthalmol. 2021 Apr 5;11206721211006573. doi: 10.1177/11206721211006573.


9) Visual Field Endpoints Based on Subgroups of Points may be Useful in Glaucoma Clinical Trials – A Study with the Humphrey Field Analyzer and the Compass perimeter

Barkana Y, Leshno A, Stern O, Singer R, Russ H, Oddone F,  Lanzetta P,  Perdicchi A,  Johnson Chris A, Garway-Heath David F, Rossetti L M, Skaat A

J Glaucoma. 2021 Apr 23. doi: 10.1097/IJG.0000000000001856.


10) Risk Factors for Retinal Ganglion Cell Distress in Glaucoma and Neuroprotective Potential Intervention

Vernazza S, Oddone F, Tirendi S, Bassi AM.

Int J Mol Sci. 2021 Jul 27;22(15):7994. doi: 10.3390/ijms22157994.


11) Glaucoma heritability: Molecular mechanisms of disease”

Zukerman R., Harris A., Oddone F., Siesky B., Verticchio Vercellin A., Ciulla T.A.

Genes (Basel). 2021 Jul 27;12(8):1135. doi: 10.3390/genes12081135.


12) Vascular biomarkers from optical coherence tomography angiography and glaucoma: where do we stand in 2021?

Shin JD., Wolf AT., Harris A., Verticchio Vercellin A., Siesky B., Rowe LW., Packles M., Oddone F.

Acta Ophthalmol. 2021 Aug 6. doi: 10.1111/aos.14982. Online ahead of print.


13) Topical carbonic anhydrase inhibitors and glaucoma in 2021: where do we stand?

Stoner A., Harris A., Oddone F., Belamkar A., Verticchio Vercellin AC., Shin J., Januleviciene I., Siesky B.

Br J Ophthalmol. 2021 Aug 25;bjophthalmol-2021-319530. doi: 10.1136/bjophthalmol-2021-319530. Online ahead of print.


14) Efficacy and Safety of PreserFlo ® MicroShunt After a Failed Trabeculectomy in Eyes with Primary Open-Angle Glaucoma: A Retrospective Study

Quaranta L., Micheletti E., Carassa R., Bruttini C., Fausto R., Katsanos A., Riva I.

Adv Ther. 2021 Aug;38(8):4403-4412. doi: 10.1007/s12325-021-01811-w. Epub 2021 Jul 12


15) Do additional testing locations improve the detection of macular perimetric defects in glaucoma?

Montesano G., McKendrick AM., Turpin A., Brusini P., Oddone F., Fogagnolo P., Perdicchi A., Johnson CA., Lanzetta P., Rossetti LM., Garway-Heath DF., Crabb DP.

Ophthalmology, June, 2021. DOI:


16) Improving event-based progression analysis in glaucomatous visual fields

Rui C., Montesano G., Crabb DP., Brusini P., Chauhan BC., Rossetti LM., Fogagnolo P., Giraud JM., Fenolland JR., Oddone F.

Sci Rep. 2021 Aug 11;11(1):16353. doi: 10.1038/s41598-021-95877-9.


17)At the cutting edge against cancer: insights into the cross-talk between the immunoproteasome and immune checkpoints.                                                                                         Grazia Raffaella Tundo *, Diego Sbardella, Francesco Oddone, Anna Kucriaeva, Pedro Miguel Lacal, Alexey Belogurov, Grazia Graziani *, Stefano Marini.

Cancers (Basel).  2021 Sep 28;13(19):4852. doi: 10.3390/cancers13194852.


18)Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells.

Benvenuto M, Ciuffa S, Focaccetti C, Sbardella D, Fazi S, Scimeca M, Tundo GR, Barillari G, Segni M, Bonanno E, Manzari V, Modesti A, Masuelli L, Coletta M, Bei R.

Sci Rep. 2021 Sep 24;11(1):19051. doi: 10.1038/s41598-021-98450-6.


19)A new look at the safety and tolerability of prostaglandin analogue eyedrops in glaucoma and ocular hypertension.

Katsanos A, Riva I, Bozkurt B, Holló G, Quaranta L, Oddone F, Irkec M, Dutton GN, Konstas AG.

Expert Opin Drug Saf. 2021 Oct 29;1-15. doi: 10.1080/14740338.2022.1996560


20)A Comparison of Hyper-Reflective Retinal Spot Counts in Optical Coherence Tomography Images from Glaucomatous and Healthy Eyes.

Quaranta L, Bruttini C, De Angelis G, Montescani S, Ardizzone A, Katsanos A, Carnevale C, Oddone F, Riva I.

J Clin Med. 2021 Oct 12;10(20):4668. doi: 10.3390/jcm10204668

21)An Innovative In Vitro Open-Angle Glaucoma Model (IVOM) Shows Changes Induced by Increased Ocular Pressure and Oxidative Stress.

Vernazza S, Tirendi S, Passalacqua M, Piacente F, Scarfì S, Oddone F (colast), Bassi AM.

Int J Mol Sci. 2021 Nov 9;22(22):12129. doi: 10.3390/ijms222212129.


22)Prevalence Rates and Risk Factors for Primary Open Angle Glaucoma in the Middle East.

Torabi R, Harris A, Siesky B, Zukerman R, Oddone F, Mathew S, Januleviciene I, Vercellin ACV.

J Ophthalmic Vis Res. 2021 Oct 25;16(4):644-656. doi: 10.18502/jovr.v16i4.9755.

1) Comparison of intraocular lens power formulas according to axial length after myopic corneal laser refractive surgery

Whang W J, Hoffer K J, Kim S J, Chung S H, Savini G

J Cataract Refract Surg. 2020 Sep 21. doi: 10.1097/j.jcrs.0000000000000445.


2) Repeatability of automated measurements by a new anterior segment optical coherence tomographer and biometer and agreement with standard devices.

Schiano Lomoriello D, Hoffer K.J, Abicca I, Savini G

Sci Rep. 2021 Jan 13;11(1):983. doi: 10.1038/s41598-020-79674-4.


3) Long-term Outcomes and Complications of the New Carlevale Sutureless Scleral Fixation Posterior Chamber IOL

Vaiano A S, Hoffer K J, Greco A, Greco A, D’Amico G, Pasqualitto V, Carlevale C, Savini G

J Refract Surg. 2021 Feb 1;37(2):126-132. doi: 10.3928/1081597X-20201207-02.


4) The Use of Anterior-Segment Optical-Coherence Tomography for the Assessment of the Iridocorneal Angle and Its Alterations: Update and Current Evidence

Triolo G, Barboni P, Savini G, De Gaetano F, Monaco G, David A, Scialdone A

J Clin Med. 2021 Jan 11;10(2):231. doi: 10.3390/jcm10020231.


5) Repeatability of total keratometry and standard keratometry by the iol master 700 and comparison to total corneal astigmatism by scheimpflug imaging

Savini G, Taroni L, Schiano Lomoriello D, Hoffer K

Eye (Lond). 2021 Jan;35(1):307-315. doi: 10.1038/s41433-020-01245-8. Epub 2020 Nov 2.


6) Clinical Accuracy of 18 IOL Power Formulas in 241 Short Eyes

Voytsekhivskyy Oleksiy V, J Hoffer Kenneth, Savini G , Tutchenko Larysa P, Fernandes D

Curr Eye Res. 2021 May 20. doi: 10.1080/02713683.2021.1933056.


7) Accuracy of New Intraocular Lens Power Calculation Formulas: A Lens Thickness Study

Taroni L, Hoffer Kenneth J, Lupardi E, Barboni P, Savini G

J Refract Surg. 2021 Mar;37(3):202-206. doi: 10.3928/1081597X-20210104-01. Epub 2021 Mar 18.


8) Color LED reflection topography: Validation of Equivalent Keratometry Reading for IOL power calculation in eyes with previous corneal myopic refractive surgery

Fernández-Rosés J , Lamarca J, Hoffer Kenneth J, Beltrán A, Barraquer Rafael I, Savini G

J Cataract Refract Surg. 2021 Jun 1. doi: 10.1097/j.jcrs.0000000000000709.


9) Reply

Hoffer Kenneth J, Savini G

Ophthalmology. 2021 Jul;128(7):e37. doi: 10.1016/j.ophtha.2021.03.020. Epub 2021 Apr 9.


10) To compare corneal confocal microscopy of eyes with Fuchs’ endothelial corneal dystrophy after two different endothelial surgeries

Schiano-Lomoriello D , Abicca I , Bono V , Giannini D , Colabelli-Gisoldi R A , Boni N , Komaiha  C, Pocobelli A

Eur J Ophthalmol. 2021 Apr 10;11206721211009451. doi: 10.1177/11206721211009451.


11) Single-Pass Mikrokeratome and Anterior Chamber Pressurizer for the Ultrathin Descemet-Stripping Automated Endothelial Keratoplasty Graft Preparation

Clerici R, Ceccuzzi R , Fausto R,  Tinelli C , Di Palma M R , Mantegna G, Riva I, Busin M , De Angelis G , Quaranta L.

Cornea. 2021 Jun 1;40(6):755-763. doi: 10.1097/ICO.0000000000002607


12) Comparison of an upgraded optical biometer with 2 validated optical biometers

Kanclerz P , Hoffer LJ., Przewłócka K., Savini G.

J Cataract Refract Surg. 2021 Jul 1;47(7):859-864. doi: 10.1097/j.jcrs.0000000000000541


13) Accuracy of IOL Power Calculation Using the New Carlevale Sutureless Scleral Fixation Posterior Chamber IOL

Vaiano AS., Hoffer KJ., Greco A., Greco A., D’Amico G., Pasqualitto V., Carlevale C., Savini G.

J Refract Surg. 2021 Jul;37(7):472-476. doi: 10.3928/1081597X-20210401-01.


14) Agreement of IOL power calculation between IOLMaster 700 and Anterion swept source optical coherence tomography-based biometers

Pfaeffli OA., Weber A., Hoffer KJ., Savini G.,  Baenninger PB., Thiel MA. Taroni L, Müller L.

J Cataract Refract Surg. 2021 Aug 18. doi: 10.1097/j.jcrs.0000000000000788.


15) The Precision of a New Anterior Segment Optical Coherence Tomographer and Its Comparison With a Swept-Source OCT-Based Optical Biometer in Patients With Cataract

Wang O., Chen M.,  Ning R., Savini G., Wang Y., Zhang T.,  Lin X., Chen X, Huang J.

J Refract Surg. 2021 Sep;37(9):616-622. doi: 10.3928/1081597X-20210610-02.


16) Reliability and agreement of the central and mid-peripheral corneal thickness measured by a new Scheimpflug based imaging

Yu AY , Ye J, Savini G, Wang  Y, Zhang T, Chen M,  Wang O, Huang J.

Ann Transl Med. 2021 Jul;9(14):1136. doi: 10.21037/atm-20-7895.


17)Corneal Subbasal Plexus in Eyes with Fuchs’ Endothelial Corneal Dystrophy after Two Different Endothelial Surgeries.

Irene Abicca , Marta Gilardi, Daniela Giannini,Rossella Anna Maria Colabelli Gisoldi, Augusto Pocobelli, and Domenico Schiano Lomoriello.

J Ophthalmol 2021 Oct 4;2021:5098272. doi: 10.1155/2021/5098272.


18)Vernal keratoconjunctivitis activity induces decrease of ocular surface CD14, TLR-4 and TLR-9 expression.

Sacchetti M, Nebbioso M, Segatto M, Abicca I, Bruscolini A, Zicari AM, Lambiase A.

Eur J Ophthalmol 2021 Oct 5;11206721211048814.doi. 10.1177/11206721211048814. 


19)Immersion Ultrasound Biometry vs. Optical Biometry.

Cooke DL, Waldron R, Savini G, Riaz KM, Taroni L, Murphy DA, Guaraldi F.

J Cataract Refract Surg. 2021 Nov 9.doi: 10.1097/j.jcrs.0000000000000865


20) Comparison of Corneal Power Calculation by Standard Keratometry and Total Keratometry in Eyes With Previous Myopic FS-LASIK

Lupardi E , Taroni L , Hoffer K J , Schiano-Lomoriello D, Savini  G

J Refract Surg. 2021 Dec;37(12):848-852. doi: 10.3928/1081597X-20211213-01.

1) Real-life patient journey in neovascular age-related macular degeneration: a narrative medicine analysis in the Italian setting

Midena E, Varano M, Pilotto E, Staurenghi G, Camparini M, Pece A, Battaglia Parodi M, Vadalà M, Donati S, Frizziero L, Fiorencis A, Marini MG, Reale L

Eye (Lond). 2021 Mar 5. doi: 10.1038/s41433-021-01470-9.


2) Exploring the biopsychosocial pathways shared by obstructive sleep apnea (OSA) and central serous chorioretinopathy (CSC)

Scarinci F, Patacchioli FR, Parravano M

Clin. Med. 2021, 10(7), 1521;


3) Using three-dimensional OCTA metrics improves repeatability on quantification of ischemia in eyes with diabetic macular edema.

Borrelli E, Parravano M, Costanzo E, MD; Sacconi R, Querques L, Pennisi F, De Geronimo D; Bandello F, Querques G

Retina. 2020 Dec 14;Publish Ahead of Print. doi: 10.1097/IAE.0000000000003077.


4) Treatment-Naïve Quiescent Macular Neovascularization secondary to AMD: The 2019 Young Investigator Lecture of Macula Society

Querques G, Sacconi R, Capuano V, Carnevali A, Colantuono D, Battista M, Borrelli E, Miere A, Parravano M, Costanzo E, Querques L, Souied EH, Bandello F

Eur J Ophthalmol. 2021 Jan 14;1120672120986370. doi: 10.1177/1120672120986370.


5) Optical Coherence Tomography Angiography Assessment of the Diabetic Macula: a Comparison Study among Different Algorithms

Borrelli E, Sacconi R, Parravano M, Costanzo E, Querques L, Battista M, Grosso D, Giorno P, Bandello F, Querques G

Retina. 2021 Feb 11. doi: 10.1097/IAE.0000000000003145.


6) Fluid as a critical biomarker in neovascular age-related macular degeneration management: literature review and consensus recommendations

Kodjikian L, Parravano M, Clemens A, Dolz-Marco R, Holz FG, Munk MR, Nicolò M, Ricci F,10 Rufino S, Talks J, Verma RK, Zarranz-Ventura J, Zweifel1 S

Eye (Lond). 2021 Apr 1. doi: 10.1038/s41433-021-01487-0


7) The Role of Imaging in Planning Treatment for Central Serous Chorioretinopathy

Da Pozzo S, Iacono P, Arrigo A, Battaglia Parodi M

Pharmaceuticals (Basel). 2021 Jan 29;14(2):105. doi: 10.3390/ph14020105


8) Characterization of macular neovascularization in geographic atrophy

Sacconi R, Brambati M, Miere A, Costanzo E, Capuano V, Borrelli E, Battista M, Parravano M,Souied E, Bandello F, Querques G

Br J Ophthalmol. 2021 Apr 9;bjophthalmol-2021-318820. doi: 10.1136/bjophthalmol-2021-318820.


9) Association Between Visual Impairment and Depression in Patients Attending Eye Clinics: A Meta-analysis

Parravano M, Petri D, Maurutto E, Lucenteforte E, Menchini F, Lanzetta P, Varano M, van Nispen Ruth M A, Virgili G.

JAMA Ophthalmol. 2021 May 27;e211557. doi: 10.1001/jamaophthalmol.2021.1557.


10) Imaging biomarkers of 1-year activity in type 1 macular neovascularization

Costanzo E, Parravano M, Giannini D,  Borrelli E,  Sacconi E, Querques G.

Transl Vis Sci Technol. 2021 May 3;10(6):18. doi: 10.1167/tvst.10.6.18.


11) Uveitis-Glaucoma-Hyphema Syndrome: Clinical Features and Differential Diagnosis

Accorinti M, Saturno M C, Paroli M P, De Geronimo D, Gilardi M

Ocul Immunol Inflamm. 2021 Apr 1;1-6. doi: 10.1080/09273948.2021.1881563.


12) Role of hemoglobin structural-functional relationships in oxygen transport.

Ciaccio C , Coletta A , Coletta M

Mol Aspects Med. 2021 Sep 9;101022. Doi: 10.1016/j.mam.2021.101022. 


13) Standardization of Optical Coherence Tomography Angiography Imaging Biomarkers in Diabetic Retinal Disease

Vujosevic S, Cunha-Vaz J, Figueira J, Löwenstein A, Midena E, Parravano M, Scanlon P H,   Simó R,    Hernández C,   Madeira M H, Marques I P,   Martinho A C-V, Santos A R, Simó-Servat O,. Salongcay R P, Zur D, Peto T

Ophthalmic Res. 2021 Jul 30.doi: 10.1159/000518620.


14) Clinical and molecular findings in patients with pattern dystrophy

Sodi A, Mucciolo DP,  Giorgio D, Passerini I, Pacini B, Bruschi M, Verdina T, Virgili G, Giansanti F, Murro V

Ophthalmic Genet. 2021 Jul 9;1-11. doi: 10.1080/13816810.2021.1938140.


15) Effectiveness of anti-vascular endothelial growth factors in neovascular age-related macular degeneration and variables associated with visual acuity outcomes: Results from the EAGLE study

Staurenghi G, Bandello F, Viola F, Varano M, Barbati B, Peruzzi E,  Bassanini S, Biancotto C, Fenicia V, Furino C, Vadalà M, Reibaldi M, Vujosevic S, Ricci F

PLoS One. 2021 Sep 1;16(9):e0256461. doi: 10.1371/journal.pone.0256461. eCollection 2021.


16) Two novel compound heterozygous SAG mutations in an Italian patient with Oguchi disease: A genetic and multimodal retinal imaging study”.

Pilotto E, Trevisson E, Nacci EB, Longhin E ,  Guidolin F , Midena E .

Eur J Ophthalmol. 2021 Jun 24;11206721211027422. doi: 10.1177/11206721211027422.


17)OCT retinal angiography features in patients with rheumatoid arthritis: A pilot study.

Iacono P*, Da Pozzo S, Bedendo A, Arrigo A, Parravano M, Varano M, Battaglia Parodi M.

Eur J Ophthalmol. 2021 Jul 27;11206721211035626.doi: 10.1177/11206721211035626


18)Volume rendered 3D OCTA assessment of macular ischemia in patients with type 1 diabetes and without diabetic retinopathy.

Enrico BorrelliDomenico GrossoMariacristina ParravanoEliana CostanzoMaria Brambati

Chiara ViganòRiccardo Sacconi, Lea QuerquesAdelaide PinaDaniele De GeronimoFrancesco Bandello, Giuseppe Querques

Sci Rep 11, 19793 (2021).


19)Anti-VEGF and other novel therapies for Neovascular Age Related Macular Degeneration: An Update.

Mariacristina Parravano*, Eliana Costanzo, Giulia Scondotto, Gianluca Trifirò, Gianni Virgili.

BioDrugs. 2021 Nov;35(6):673-692. doi: 10.1007/s40259-021-00499-2.


20)Outcome and genetic analysis of patients affected by retinal capillary hemangioblastoma in von Hippel Lindau syndrome.

 Murro V, Lippera M, Mucciolo DP, Canu L, Ercolino T, De Filpo G, Giorgio D, Traficante G, Sodi A, Virgili G, Giansanti F.

Mol Vis. 2021 Sep 2;27:542-554. eCollection 2021. PMID: 34566400


21)Femto-assisted versus conventional phacoemulsification differently impact on choroid structure after surgery.

Appolloni R, Viggiano P*, Carrella ML, Evangelista F, Appolloni A, Toto L, Mastropasqua L.

Eur J Ophthalmol. 2021 Sep 29;11206721211048360.doi: 10.1177/11206721211048360


22)Effects of hydroxychloroquine on retinal vessel density in patients with rheumatoid arthritis over 1-year follow-up: a pilot study.

Pierluigi Iacono *, Stefano Da Pozzo, Alberto Bedendo, Monica Varano, Mariacristina Parravano.

Appl. Sci. 2021, 11, 9837. https://


23)Lamellar Hole-associated Epiretinal Proliferation in choroideremia: a case report.

Murro V, Mucciolo DP, Giorgio D, Caporossi T, Passerini I, Bani D, Giansanti F, Virgili G, Sodi A.

Int J Retina Vitreous. 2021 Oct 19;7(1):63. doi: 10.1186/s40942-021-00333-5


24)Differences in cysts characteristics and related influence on the anatomical response after dexamethasone implant in diabetic macular oedema.

Mariacristina Parravano, Serena Fragiotta, Eliana Costanzo, Daniela Giannini, Daniele De Geronimo, Pasquale Viggiano, Riccardo Sacconi, and Giuseppe Querques.

Eye (Lond). 2021 Nov 24. doi: 10.1038/s41433-021-01857-8 


25) Effectiveness of a hydrophilic curcumin-based formulation in coadjuvating the therapeutic effect of intravitreal dexamethasone in subjects with diabetic macular edema.

Mariacristina Parravano*, Davide Allegrini, Adriano Carnevali, Eliana Costanzo, Giuseppe Giannaccare, Paola Giorno, Vincenzo Scorcia, Giorgio Alfredo Spedicato, Monica Varano, Mario Romano.


  • 26) Relationship of Choroidal Vasculature and Choriocapillaris Flow With Alterations of Salivary α-Amylase Patterns in Central Serous Chorioretinopathy Scarinci F, Patacchioli F R, CostanzoE, Parravano M.
  • Invest Ophthalmol Vis Sci. 2021 Dec 1;62(15):19. doi: 10.1167/iovs.62.15.19.
  • 27) Novel approaches to the assessment and treatment of lamellar macular hole.
  • Frisina R, Tozzi L, Gius I, Pilotto E, Midena E

Acta Ophthalmol. 2021 Dec 13. doi: 10.1111/aos.15078.

1) Cataract Surgery Practice Patterns Worldwide: A Survey

Rossi T, Romano MR, Iannetta D, Romano V, Gualdi L, D’Agostino I, Ripandelli G

BMJ Open Ophthalmol. 2021 Jan 13;6(1):e000464. doi: 10.1136/bmjophth-2020-000464. eCollection 2021.


2) Epiretinal Membrane Surgery: Structural Retinal Changes Correlate with the Improvement of Visual Function

Cacciamani ACosimi PRipandelli GDi Nicola MScarinci F

J Clin Med. 2020 Dec 29;10(1):90. doi: 10.3390/jcm10010090


3) Influence of Anterior Capsulorhexis Shape, Centration, Size and Location on Intraocular Lens Position: A finite Element Model.

Rossi T, Ceccacci Deng A, Testa G, Ruggiero A, Bonora N,  D’Agostino I, Telani,S Ripandelli G.

J Cataract Refract Surg. 2021 Jun 7.doi: 10.1097/j.jcrs.0000000000000711


4) Computational Fluid Dynamics of Intraocular Silicone Oil Tamponade

Rossi T, Querzoli G, Badas MG, Angius F, Telani S, Ripandelli G.

Trans Vis Sci Technol. 2021 Jul 1; 10(8):22. doi:10.1167/tvst.10.8.22.


5) Inner Macular Changes in Fellow Eye of Patients With Unilateral Idiopathic Epiretinal Membrane

Coppe AM, Lapucci G, Ripandelli G, Pesci FR, Buzzonetti L, Iarossi G.

Invest Ophthalmol Vis Sci. 2021 Aug 2; 62 (10):29. Doi:10.1167/iovs.62.10.29


6) Topo-Pachimetric Accelerated Epi-On Cross-Linking Compared to the Dresden Protocol Using Riboflavin with Vitamin E TPGS: Results of a 2 Year Randomized Study

Caruso C, Epstein RL, Troiano P, Napolitano F, Scarinci F, Costagliola C.

J Clin Med. 2021 Aug 25; 10(17):3799. doi: 10.3390/jcm.10173799


7) The Prophylaxis of Fellow-Eye Retinal Detachment in Stickler Syndrome. A Retrospective Series

Ripandelli G, Rossi T, Pesci FR, Cecere M, Stirpe M.

Retina. 2021 Sep 14.doi: 10.1097/IAE.0000000000003304

1) Severe retinopathy of prematurity is associated with early post-natal low platelet count

Parrozzani R, Nacci EB, Bini S, Marchione G, Salvadori S, Nardo D, Midena E

Sci Rep. 2021 Jan 13;11(1):891. doi: 10.1038/s41598-020-79535-0.


2) Intraocular fluid biomarkers (liquid biopsy) in human diabetic retinopathy

Midena E, Frizziero L, Midena G, Pilotto E.

Graefes Arch Clin Exp Ophthalmol. 2021 Jul 3. doi: 10.1007/s00417-021-05285-y.


3) Structural and microvascular changes of the peripapillary retinal nerve fiber layer in Von Hippel-Lindau disease: an OCT and OCT angiography study

Pilotto E, Nacci EB, De Mojà G, Ferrara AM, Parrozzani R, Londei D, Zovato S, Midena E

Sci Rep. 2021 Jan 8;11(1):25. doi: 10.1038/s41598-020-79652-w


4) Subthresold micropulse laser modulates retinal neuroinflammatory biomarkers in diabetic macular edema”

Frizziero L, Calciati A, Torresin T, Midena G, Parrozzani R, Pilotto E, Midena E.

J Clin Med. 2021 Jul 15;10(14):3134. doi: 10.3390/jcm10143134.


5) Diabetic macular edema treated with 577-nm subthreshold micropulse laser: a real-life, long-term study

Frizziero L, Calciati A, Torresin T, Midena G, Parrozzani R, Pilotto E, Midena E.

J Pers Med. 2021 May 13;11(5):405. doi: 10.3390/jpm11050405.


6) OCT Hyperreflective Retinal Foci in diabetic retinopathy: an automatic detection comparative study”

Midena E, Torresin T, Velotta E, Pilotto E, Parrozzani R, Frizziero L

Front Immunol. 2021 Apr 22;12:613051. doi: 10.3389/fimmu.2021.613051. eCollection 2021


7) Early microvascular and oscillatory potentials changes in human diabetic retina: amacrine cells and the intraretinal neurovascular crosstalk”

Midena E, Torresin T, Longhin E, Midena G, Pilotto E, Frizziero L.

Clin. Med. 2021, 10(18), 4035;


8)Thrombocytopenia as Type 1 ROP biomarker: a longitudinal study.

Raffaele Parrozzani *, Giulia Marchione, Alberto Fantin, Luisa.

J Pers Med. 2021 Oct 30;11(11):1120. doi: 10.3390/jpm11111120


9)Radiation Maculopathy is Anticipated by OCT Hyperreflective Retinal Foci: a Large, Prospective Confirmation study.

Parrozzani R, Midena G, Frizziero L, Marchione G, Midena E.

Retina. 2021 Nov 19. doi: 10.1097/IAE.0000000000003359.


10) Retinal Glial Cells in Von Hippel- Lindau Disease: a Novel Approach in the Pathophysiology of Retinal Hemangioblastoma

Pilotto E , Midena G,  Torresin T, De Mojà G, Bacelle ML, Ferrara AM, Zovato S, and Midena E.

Cancers 2022, 14(1), 170;


11) Endogenous Trichosporon Asahii Retinitis

Parrozzani R, Marchione G, Midena G.

Ophthalmology. 2022 Jan;129(1):66. doi: 10.1016/j.ophtha.2021.05.001.

1) Correlations between visual morphological, functional and psychophysical changes in chronic non-arteritic ischemic optic neuropathy

Barbano L, Ziccardi L, Parisi V

Graefes Arch Clin Exp Ophthalmol. 2021 Jan 7. doi: 10.1007/s00417-020-05023-w.


2) USH2A-Related Retinitis Pigmentosa: Staging of Disease Severity and Morpho-Functional Studies

Falsini B, Placidi G, De Siena E, Savastano MC, Minnella AG, Maceroni M, Midena G, Ziccardi L, Parisi V, Bertelli M, Maltese PE, Chiurazzi P, Rizzo S

Diagnostics (Basel). 2021 Feb 1;11(2):213. doi: 10.3390/diagnostics11020213


3) Fluorescein Angiography Findings in Eyes With Lamellar Macular Hole and Epiretinal Membrane Foveoschisis

Dell’Omo R, Filippelli M, De Turris S, Cimino L, Steel DH, Pavesio CE, Govetto A, Chehaibou I, Parmeggiani F, Romano MR, Ziccardi L, Pirozzi E, Costagliola C

Invest Ophthalmol Vis Sci. 2021 Jan 4;62(1):34. doi: 10.1167/iovs.62.1.34.


4) Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference

De Tommaso M, Vecchio E, Quitadamo SV, Coppola G, Di Renzo A, Parisi V, Silvestro M, Russo A, Tedeschi G

Brain Sci. 2021 Feb 13;11(2):234. doi: 10.3390/brainsci11020234.


5) Genetics Influences Drug Consumption in Medication Overuse Headache, Not in Migraine: Evidence From Wolframin His611Arg Polymorphism Analysis

Di Lorenzo C, Di Lorenzo G, Coppola G, Parisi V, Gaetano S Grieco GS, Santorelli FM, Pascale E, Pierelli F

Front Neurol. 2021 Jan 22;11:599517. doi: 10.3389/fneur.2020.599517. eCollection 2020.


6) Visual Evoked Potential Responses after Photostress in Migraine Patients and Their Correlations with Clinical Features

Coppola G, Di Lorenzo C, Di Lenola D, Serrao M, Pierelli F, Parisi V

J Clin Med. 2021 Mar 2;10(5):982. doi: 10.3390/jcm10050982.


7) Spectral domain optical coherence tomography assessment in treatment-naïve patients with clinically isolated syndrome anda different multiple sclerosis types: findings and relationship with the disability status.

Rzepiński L, Kucharczuk J, , Maciejek Z, Grzybowski A, Parisi V.

Clin. Med. 2021, 10, 2892 doi: 10.3390/jcm10132892


8) Pathophysiological bases of comorbidity in migraine

Altamura C, Corbelli I, de Tommaso M, Di Lorenzo C, Di Lorenzo G, Di Renzo A, Filippi M, Jannini T, Messina R, Parisi P, Parisi V, Pierelli F, Rainero I, Raucci U, Rubino E, Sarchielli P, Li L, Vernieri F, Vollono C, Coppola G.

Frontiers in Human Neuroscience  2021 Apr 20;15:640574.


9) Thalamo-cortical networks in subtypes of migraine with aura patients

Coppola G, Di Renzo A, Tinelli E, Petolicchio B, Parisi V, Serrao M, Porcaro C, Fiorelli M, Caramia F, Schoenen J, Di Piero V, Pierelli F.

J Headache Pain. 2021 Jun 19;22(1):58


10) Fampridine improves acute optic neuritis contributing to a long‑lasting recovery of nerve function

Boffa L, Albanese M, Ziccardi L, Aiello F, Cesereo M, Parisi V. Mercuri N,

Neurological Sciences Aug 13. doi: 10.1007/s10072-021-05548-w.


11) Assessment of macular function by multifocal electroretinogram in multiple sclerosis patients treated with fingolimod

Barbano L, Ziccardi L, Landi D, Gabri Nicoletti C, Mataluni G, Falsini B, Centonze D, Marfia GA, Quaranta L, Parisi V.

Advanced in Therapy, 2021 Jul;38(7):3986-3996. Doi:10.1007/s12325-021-01728-4


12) Hypothalamic structural integrity and temporal complexity of cortical information processing at rest in migraine without aura patients between attacks

Porcaro C, Di Renzo A, Tinelli E, Di Lorenzo G, Seri S, Parisi V, Caramia F, Fiorelli M, Di Piero V, Pierelli F, Coppola G.

Sci Rep Sep 21;11(1):18701. Doi: 10.1038/s41598-021-98213-3


13)Macular Morpho-Functional and Visual Pathways Functional Assessment in Patients with Spinocerebellar Type 1 Ataxia with or without Neurological Signs.

Lucia Ziccardi, Ettore Cioffi, Lucilla Barbano,*, Valeria Gioiosa, Benedetto Falsini, Carlo Casali and Vincenzo Parisi.

J Clin Med. 2021 Nov 12;10(22):5271.doi: 10.3390/jcm10225271.

1) Nerve Growth Factor (NGF) modulates in vitro induced myofibroblasts by highlighting a differential protein signature

Esposito G, Balzamino B O, Stigliano E, Biamonte F, Urbani A, Micera A

Sci Rep. 2021 Jan 18;11(1):1672. doi: 10.1038/s41598-021-81040-x.


2) Retrobulbar administration of purified anti-nerve growth factor in developing rats induces structural and biochemical changes in the retina and cornea

Aloe L, Rocco M L, Balzamino B O, Esposito G, Micera A

Int J Ophthalmol. 2021 Feb 18;14(2):209-216. doi: 10.18240/ijo.2021.02.05. eCollection 2021.


 3) Response and Toxicity to Cytarabine Therapy in Leukemia and Lymphoma: From Dose Puzzle to Pharmacogenomic Biomarkers

Di Francia R, Crisci S, De Monaco A, Cafiero A, Re A, Iaccarino G, De Filippi R, Frigeri F, Corazzelli G, Micera A, Pinto A

Cancers (Basel). 2021 Feb 25;13(5):966. doi: 10.3390/cancers13050966


4) Biomarkers of Neurodegeneration and Precision Therapy in Retinal Disease

Micera A, Balzamino B O, Di Zazzo A, Dinice L, Bonini S, Coassin M

Front Pharmacol. 2021 Jan 18;11:601647. doi: 10.3389/fphar.2020.601647


 5) Anti-inflammatory role of curcumin in retinal disorders (Review).

Franzone F, Nebbioso M, Pergolizzi T, Attanasio G, Musacchio A, Greco A, Limoli PG, Artico M, Spandidos DA, Taurone S, Agostinelli E.

Exp Ther Med. 2021 Jul;22(1):790. doi: 10.3892/etm.2021.10222.


6) Relaxation Response in Stressed Volunteers: Psychometric Tests and Neurotrophin Changes in Biological Fluids

Zappella M, Biamonte F, Balzamino BO, Manieri R, Cortes M, Santucci D, Di Stasio E, Rizzuto M, Micera A.

Front Psychiatry. 2021 Jun 17;12:655453. doi: 10.3389/fpsyt.2021.655453


7) Sex Hormones Related Ocular Dryness in Breast Cancer Women

Grasso A, Di Zazzo A, Giannaccare G, Sung J, Inomata T, Shih KC, Micera A, Gaudenzi D, Spelta S, Romeo MA, Orsaria P, Coassin M, Altomare V.

J Clin Med. 2021 Jun 14;10(12):2620. doi: 10.3390/jcm10122620.


8) Keratoconus: the possible involvement of inflammatory cytokines in its pathogenesis. An experimental study and review of the literature

Taurone S, Ralli M, Plateroti A M, Scorcia V, Greco A, Nebbioso M, Soda G, Artico M, Familiari P, Papa V, Gobbi P, Micera A

Eur Rev Med Pharmacol Sci. 2021 Jul;25(13):4478-4489. doi10.26355/eurrev_202107_26239.


9) Ocular Surface Failure in Urban Syndrome

Antonini M, Gaudenzi D, Spelta S, Sborgia G, Poddi M, Micera A, Sgrulletta R, Coassin M, Di Zazzo A.

J Clin Med. 2021 Jul 9;10(14):3048.  doi: 10.3390/jcm10143048


10)Should we care about the ocular surface in the anophthalmic patient?

Volpe G, De Piano M, Mazzone G, Micera A*, Bonini S, Modugno AC.

Eur J Ophthalmol. 2021 Oct 7;11206721211048803.doi: 10.1177/11206721211048803.


11)Allergic eye disease: Blocking LTB4/C5 in vivo suppressed disease and Th2 & Th9 cells.

Eskandarpour M, Zhang X, Micera A, Zaher S, Larkin FDP, Nunn M, Bonini S, Weston-Davies W, Calder VL.

Allergy. 2021 Oct 6.doi: 10.1111/all.15128.


12)Tau Cleavage Contributes to Cognitive Dysfunction in Strepto-Zotocin-Induced Sporadic Alzheimer’s Disease (sAD) Mouse Model.

Latina V, Giacovazzo G, Calissano P, Atlante A, La Regina F, Malerba F, Dell’Aquila M, Stigliano E, Balzamino BO, Micera A, Coccurello R, Amadoro G.

Int J Mol Sci. 2021 Nov 10;22(22):12158.doi: 10.3390/ijms222212158.

1) Citicoline in ophthalmological neurodegenerative disease: a comprehensive review

Oddone F, Rossetti L, Parravano M, Sbardella D, Coletta M, Ziccardi L, Roberti G, Carnevale C, Romano D, Manni G, Parisi V

Pharmaceuticals (Basel). 2021 Mar 20;14(3):281.doi: 10.3390/ph14030281



2) Neural conduction along post-retinal visual pathways in glaucoma

Parisi  V, Ziccardi L*, Tanga L, Roberti G, Barbano L, Carnevale C, Manni G. and Oddone F.

Front. Aging Neurosci., 02 August 2021



3) Nerve Growth Factor (NGF)-based therapy in Alzheimer’s Disease (AD) and Age-related Macular Degeneration (AMD)

Amadoro G, Latina V, Balzamino B J, Squitti R,  Varano M, Calissano P, Micera A*

Front. Neurosci., 09 September 2021.



4) Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes

Parravano M, Ziccardi L, Borrelli E, Costanzo E, Frontoni S, Picconi F, Parisi V, Sacconi R, Di Renzo A, Varano M, Querques G

Sci Rep. 2021 Jul 26;11(1):15183. doi: 10.1038/s41598-021-94580-z.



5) Angiotensin System Polymorphisms’ in SARS-CoV-2 Positive Patients: Assessment Between Symptomatic and Asymptomatic Patients: A Pilot Study

Cafiero C, Rosapepe F,  Palmirotta R, Re A, Ottaiano MP, Benincasa G, Perone R,  Varriale E, D’Amato G, Cacciamani C, Micera A, Pisconti S.

Pharmgenomics Pers Med. 2021 May 27; 14:621-629. doi:10.2147/PGPM.S303666



6) Phacoemulsification and nucleic acid-enriched aerosol: considerations from an eye model of cataract simulation.

Cacciamani A, Scarinci F, Bruno L, Balzamino BO, Cafiero C, Re A, Cosimi P, Ripandelli G, Micera A.

Graefes Arch Clin Exp Ophthalmol.  2021 Aug 26:1-7.doi: 10.1007/s00417-021-05350-6. Online ahead of print.



7) NGF in Inflammatory and Neurodegenerative Diseases of the Eye: New Findings Supporting Neuroprotection and Proper Tissue Remodeling in Vitreoretinal Disorders”.

Esposito G, Balzamino BO, Bruno L, Cacciamani A, Micera A.

Adv Exp Med Biol. 2021;1331:265-273. doi: 10.1007/978-3-030-74046-7_18



8) Citicoline and vitamin B12 eye drops in type 1 diabetes: results of a 36 months pilot study evaluating macular electrophysiological changes

Parisi V, Ziccardi L, Barbano L, Giorno P, Varano M, Parravano M

Adv Ther 2021 Jul;38(7):3924-3936. doi: 10.1007/s12325-021-01771-1. Epub 2021 Jun 5.



9)Agreement of rebound and applanation tonometry intraocular pressure measurements during atmospheric pressure change.

Vercellin AV, Harris A, Siesky B, Zukerman R, Tanga L, Carnevale C, Scarinci F, Oddone F.

PLoS One. 2021 Oct 28;16(10):e0259143. doi: 10.1371/journal.pone.0259143. 



10) Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a  mouse model of  Alzheimer’s Disease

Latina V; Giacovazzo G; Cordella F; Balzamino BO; Micera A; Varano M; Marchetti C; Malerba F; Florio R; Atlante A; Coccurello R; Di Angelantonio S; Calissano P; Amadoro G

Acta Neuropathol Commun. 2021 Mar 9;9(1):38. doi: 10.1186/s40478-021-01138-1.



11) Relationship of Choroidal Vasculature and Choriocapillaris Flow With Alterations of Salivary α-Amylase Patterns in Central Serous Chorioretinopathy Scarinci F, Patacchioli F R, CostanzoE, Parravano M.

Invest Ophthalmol Vis Sci. 2021 Dec 1;62(15):19. doi: 10.1167/iovs.62.15.19.



12) Real-life patient journey in neovascular age-related macular degeneration: a narrative medicine analysis in the Italian setting

Midena E , Varano M., Pilotto E , Staurenghi G, Camparini M , Pece  A , Battaglia Parodi  M ,  Vadalà  M , Donati  S ,  Frizziero L ,  Fiorencis A , Marini M.G. ,  Reale  L.

Eye (Lond) 2022 Jan;36(1):182-192.doi: 10.1038/s41433-021-01470-9. Epub 2021 Mar 5.